White sharks (Carcharodon carcharias) are critical regulators of marine biodiversity and ecosystem function, but have suffered major declines since the 1970’s due to human related pressures. Despite efforts to protect the species, conservation remains complicated by increasing frequencies of human-shark interactions and critical knowledge gaps with the species’ biology and ecology. Understanding patterns of biological connectivity across the species range is particularly important for informing conservation management. Australian white sharks currently consist of two genetically distinct populations (southern-western and eastern Australia), however, these studies were limited to small sample sizes and traditional genetic marker systems. We revisit the population genetic status of Australian white sharks using modern genomic approaches and > 700 tissue samples. Population genetic analyses revealed a lack of genetic structure and a large number of 1st and 2nd degree relationships between white sharks from southern-western and eastern Australia, indicating a pattern of panmixia and challenging previous studies. Analyses also revealed a staggeringly high number of full and half-sibling relationships among subadult white sharks from eastern Australia, highlighting risks of inbreeding and the need for comprehensive assessments of effective population sizes. These findings will be discussed in the context of future conservation and management of Australian white sharks.